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Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

Diversification of bacterial genome content through distinct mechan...
Published: November, 2014
Abstract: Bacterial populations often consist of multiple co-circulating lineages. Determining how such population structures arise requires understanding wh... Read more »
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Megaruptor
Global quantitative proteomics reveals novel factors in the ecdyson...
Published: November, 2014
Abstract: The ecdysone signaling pathway plays a major role in various developmental transitions in insects. Recent advances in the understanding of ecdysone... Read more »
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Bioruptor Cell Lysis Mass Spectrometry
Emergence of scarlet fever Streptococcus pyogenes emm12 clones in H...
Published: November, 2014
Abstract: A scarlet fever outbreak began in mainland China and Hong Kong in 2011 (refs. 1–6). Macrolide- and tetracycline-resistant Streptoco... Read more »
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Megaruptor
Identification of Cdca7 as a novel Notch transcriptional target inv...
Published: November, 2014
Abstract: Hematopoietic stem cell (HSC) specification occurs in the embryonic aorta and requires Notch activation; however, most of the Notch-regulated eleme... Read more »
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Bioruptor Chromatin Shearing
Protein arginine methyltransferase 5 is a key regulator of the MYCN...
Published: November, 2014
Abstract: Approximately half of poor prognosis neuroblastomas (NBs) are characterized by pathognomonic MYCN gene amplification and MYCN over-expression. Here... Read more »
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Bioruptor Cell Lysis
MicroRNAs 206 and 21 Cooperate To Promote RAS-Extracellular Signal-...
Published: November, 2014
Abstract: Despite the low prevalence of activating point mutation of RAS or RAF genes, the RAS-extracellular signal-regulated kinase (ERK) pathway is implica... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
The role of maternal-specific H3K9me3 modification in establishing ...
Published: November, 2014
Abstract: Maintaining a single active X-chromosome by repressing Xist is crucial for embryonic development in mice. Although the Xist activator RNF12/RLIM is... Read more »
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LowCell ChIP kit
Fission yeast Cactin restricts telomere transcription and elongatio...
Published: November, 2014
Abstract: The telomeric transcriptome comprises multiple long non-coding RNAs generated by transcription of linear chromosome ends. In a screening performed ... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Inhibition of osteoclastogenesis and inflammatory bone resorption b...
Published: November, 2014
Abstract: Emerging evidence suggests that RANKL-induced changes in chromatin state are important for osteoclastogenesis, but these epigenetic mechanisms are ... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Decoupling of evolutionary changes in transcription factor binding ...
Published: November, 2014
Abstract: To understand the evolutionary dynamics between transcription factor (TF) binding and gene expression in mammals, we compared transcriptional outpu... Read more »
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Bioruptor
Structure-guided mutational analysis reveals the functional require...
Published: November, 2014
Abstract: DOT1 enzymes are conserved methyltransferases that catalyse the methylation of lysine 79 on histone H3 (H3K79). Most eukaryotes contain one DOT1 en... Read more »
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Bioruptor Cell Lysis
Epigenetic Modification of Histone 3 Lysine 27: Mediator Subunit ME...
Published: November, 2014
Abstract: The Mediator complex is vital for the transcriptional regulation of eukaryotic genes. Mediator binds to nuclear receptors at target response elemen... Read more »
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Bioruptor Chromatin Shearing
Suppression of the FOXM1 transcriptional programme via novel small ...
Published: November, 2014
Abstract: The transcription factor FOXM1 binds to sequence-specific motifs on DNA (C/TAAACA) through its DNA-binding domain (DBD) and activates proliferation... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
HIV-1 Integrase Variants Retarget Viral Integration and Are Associa...
Published: November, 2014
Abstract: Distinct integration patterns of different retroviruses, including HIV-1, have puzzled virologists for over 20 years. A tetramer of the viral integ... Read more »
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Bioruptor Chromatin Shearing ChIP-seq
Mating-type switching by chromosomal inversion in methylotrophic ye...
Published: November, 2014
Abstract: Saccharomyces cerevisiae has a complex system for switching the mating type of haploid cells, requiring the genome to have three mating-type (MAT)-... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Heavy transcription of yeast genes correlates with differential los...
Published: November, 2014
Abstract: Eukaryotic chromatin is composed of nucleosomes, which contain nearly two coils of DNA wrapped around a central histone octamer. The octamer contai... Read more »
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Bioruptor Chromatin Shearing ChIP-seq Bioruptor Plus
SNP-guided identification of monoallelic DNA-methylation events fro...
Published: November, 2014
Abstract: Monoallelic gene expression is typically initiated early in the development of an organism. Dysregulation of monoallelic gene expression has alread... Read more »
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MethylCap
Epigenetic modifications of gene promoter DNA in the liver of adult...
Published: November, 2014
Abstract: Testosterone (T) is known to masculinize the female phenotype of the liver, evidenced as up- and down-regulated expressions of male- and female-pre... Read more »
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MeDIP kit
Serine Deprivation Enhances Anti-neoplastic Activity of Biguanides.
Published: November, 2014
Abstract: Metformin, a biguanide widely used in the treatment of type II diabetes, clearly exhibits anti-neoplastic activity in experimental models and has b... Read more »
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Bioruptor Cell Lysis Mass Spectrometry
Combining MeDIP-seq and MRE-seq to investigate genome-wide CpG meth...
Published: November, 2014
Abstract: DNA CpG methylation is a widespread epigenetic mark in high eukaryotes including mammals. DNA methylation plays key roles in diverse biological pro... Read more »
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DNA shearing Bioruptor
Heterochromatin-mediated gene silencing facilitates the diversifica...
Published: November, 2014
Abstract: An astounding property of the nervous system is its cellular diversity. This diversity, which was initially realized by morphological and electroph... Read more »
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DNA shearing
DNA Copy-Number Control through Inhibition of Replication Fork Prog...
Published: November, 2014
Abstract: Proper control of DNA replication is essential to ensure faithful transmission of genetic material and prevent chromosomal aberrations that can dri... Read more »
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Bioruptor Chromatin Shearing ChIP-seq Bioruptor Plus
Silica nanoparticles induce autophagy and endothelial dysfunction v...
Published: November, 2014
Abstract: Although nanoparticles have a great potential for biomedical applications, there is still a lack of a correlative safety evaluation on the cardiova... Read more »
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Bioruptor
The repair of oxidized purines in the DNA of human lymphocytes requ...
Published: November, 2014
Abstract: 8-Oxoguanine DNA glycosylase (OGG1), which initiates the repair of DNA purine modifications such as 8-oxo-7,8-dihydroguanine (8-oxoG), is often reg... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR Bioruptor Plus
A phylogenomic analysis of turtles.
Published: November, 2014
Abstract: Molecular analyses of turtle relationships have overturned prevailing morphological hypotheses and prompted the development of a new taxonomy. Here... Read more »
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DNA shearing Bioruptor
The LXR-Idol Axis Differentially Regulates Plasma LDL Levels in Pri...
Published: November, 2014
Abstract: The LXR-regulated E3 ubiquitin ligase IDOL controls LDLR receptor stability independent of SREBP and PCSK9, but its relevance to plasma lipid level... Read more »
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Master Mix
A variably occupied CTCF binding site in the Ultrabithorax gene in ...
Published: November, 2014
Abstract: Although the majority of genomic binding sites for the insulator protein CTCF are constitutively occupied, a subset show variably occupancy. Such v... Read more »
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Bioruptor Chromatin Shearing
Detection of single nucleotide polymorphisms in Plasmodium falcipar...
Published: November, 2014
Abstract: Resistance of Plasmodium falciparum to some antimalarial drugs is linked to single nucleotide polymorphisms (SNPs). Currently there are no methods ... Read more »
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Bioruptor
Deregulation of Rb-E2F1 axis causes chromosomal instability by enga...
Published: November, 2014
Abstract: E2F family of transcription factors regulate genes involved in various aspects of cell cycle. Beyond the well-documented role in G1/S transition, m... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
A Novel Mouse Model for the Hyper-IgM Syndrome: A Spontaneous Activ...
Published: November, 2014
Abstract: We describe a spontaneously derived mouse line that completely failed to induce Ig class switching in vitro and in vivo. The mice inherited abolish... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR Bioruptor Plus

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